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8. 2,3-bisphosphoglycerate (BPG) is an allosteric effector of hemoglobin (Hb). Explain how binding of BPG to...

8. 2,3-bisphosphoglycerate (BPG) is an allosteric effector of hemoglobin (Hb). Explain how binding of BPG to Hb is able to alter the affinity of Hb for oxygen.

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Answer #1

Binding of 2,3-bisphosphoglycerate (BPG ) to hemoglobin (Hb) is able to alter the affinity of Hb for oxygen as in heterotropic allosteric effect where 2,3-bisphosphoglycerate helps Hb protein binding oxygen molecule for more oxygen to be delivered to body tissues .

But pH, carbon dioxide and Bisphosphoglycerate (BPG) can have an effect on the hemoglobin as in the cell, when the pH decrease, it lowers the affinity of oxygen and therefore becomes more efficient oxygen tranporter.

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