acetaminophen contains amide group and phenolic group.. While preparing the acetaminophen, acetylchloride is an one of the starting reactant. So, if excess of acetylchloride is present in the mixture. water can be used to remove acetyl chloride.
Therefore, acetaminophen contains, amide linkage it may broken down in the presence of water.
And also acetaminophen can dissolve in water, because compound is polar.
Based on these facts water need to be used in minimum.
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