Question

Determine if exposure by oral ingestion to the chemicals xylene, toluene, arsenic and hexavalent chromium poses...

Determine if exposure by oral ingestion to the chemicals xylene, toluene, arsenic and hexavalent chromium poses a noncarcinogenic health risk. The chemical specific reference doses (mg/kg-day) obtained from IRIS are xylene (0.2), toluene (0.8), arsenic (0.0003), and hexavalent chromium (0.003). Assume a 70 kg individual consumes 2 L of water per day with these chemicals at dissolved concentrations of 1 mg/L.

Homework Answers

Answer #1

The chemical specific reference dose for xylene = 0.2 mg/Kg-day

(a) since the individual is 70 kg, therefore the reference dose for the individual for xylene would be 0.2 X 70 = 14 mg/day

(b) reference dose for the individual for toluene would be 0.8 X 70 = 56 mg/day

(c) reference dose for the individual for arsenic would be 0.0003 X 70 = 0.021 mg/day

(d) reference dose for the individual for hexavalent chromium would be 0.003 X 70 = 0.21 mg/day

Since the individual drinks 2L of water with concentration of each of the chemicals is 1mg/L, so the individual is consuming 1 X 2 = 2 mg of all the chemicals per day.

So any of the chemical, whose chemical reference is less than 2 mg per day for the individual, that chemical will poses a noncarcinogenic health risk. Thus the those chemicals are arsenic and hexavalent chromium

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