Glycine has the zwitterion structure shown in the following figure. The pK a's and pI are listed. Given this information, what form of the molecule will predominate at the indicated pH values?
Part A
pH 1.0
Draw the molecule by placing atoms on the grid and connecting them with bonds. Include all hydrogen atoms. Show the formal charges of all charged atoms in the correct structure.
Part B
pH 6.0
Draw the molecule by placing atoms on the grid and connecting them with bonds. Include all hydrogen atoms. Show the formal charges of all charged atoms in the correct structure.
Part C
pH 11.0
Draw the molecule by placing atoms on the grid and connecting them with bonds. Include all hydrogen atoms. Show the formal charges of all charged atoms in the correct structure.
The structure is not given however the glycine structure is
pKa = 2.34 and pKa2 9.60 , so pI = 5.97
(i) Below pH = 2.34 , amino acid will be positive
(ii) above 9.60 , amino acid will be negative
(iii) at pH = 6: it will have both positive and negative charge
so we can draw the strucrture of glycine at given different pH:
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