Question

Which of the following statements is TRUE about hexokinase in glycolysis? Question options:

Hexokinase catalyzes the production of fructose 1,6-bisphosphate.

Hexokinase changes conformation when substrates bind.

The binding site of hexokinase is located at a cleft between two lobes.

Both the second and third answers are true.

Answer 1

Ans.

Hexokinase does not catalyze the production of fructose-1,6-bisphosphate. The production of fructose-1,6-bisphosphate from fructose-6-phosphate is catalyzed by enzyme phosphofructokinase.

Therefore, the first statement is false.

Hexokinase catalyzes the conversion of glucose to glucose-6-phosphate. Hexokinase induces conformational change when it binds to glucose and prevents the hydrolysis of ATP.

Therefore, the second statement is true.

It is true that the active site of Hexokinase is located at a cleft between two lobes.

Therefore, the third statement is also true.

So, both the second and the third statements are true.