Question

A highly volatile toxicant ‘VOLH’ has a high blood:gas partition coefficient whereas a second highly volatile toxicant ‘VOLL’ has a blood:gas partition coefficient that is very low. When each of these toxicants is administered via inhalation (at equivalent concentrations in air) - with which toxicant will it be more difficult to attain a saturating blood concentration by inhaling the substance? Explain your choice in adequate detail.

Answer 1

Blood gas partition coefficient is inversely related to induction rate. so here, VOLL will get easily dissolved in the blood, also it will be easier to take it out of the blood because it has smaller blood gas partition coefficient.

Also, this answer is supported by Henry's law, which states that "At a constant temperature, the amount of a given gas that dissolves in a given type and volume of liquid is directly proportional to the partial pressure of that gas in equilibrium with that liquid." An equivalent way of stating the law is that the solubility of a gas in a liquid is directly proportional to the partial pressure of the gas above the liquid.

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