Question

Explain why an “enzyme” that preferentially stabilizes its Michaelis complex more than the transition state does not catalyze a reaction.

Answer 1

Enzyme catalyzed reaction by forming Michaelis Complex , which is intermediate step in enzyme-catalyzed reaction. The formation of most stable intermediate increase the rate of the reaction. Enzyme can react with all substrate to form product .

But in the case of transition state it don't react with enzyme but the activation energy of reactions gets low so one easily overcome activation energy for the reaction. Enzyme don't reduce activation energy but it form stable intermediate so enzyme stabilize Michaelis complex .