Question

List factors that make it advantageous for peptide hormones to be synthesized as inactive prohormones that are activated by proteolytic cleavage.

List factors that make it advantageous for peptide hormones to be synthesized as inactive prohormones that are activated by proteolytic cleavage.

Check all that apply.

Check all that apply.

	Stabilization of not working folding of protogormone.
	Suppression of the hormonal signal until it is needed.
	Signal sequence on the prohormone molecule could direct the protein to the correct subcellular site, then be cleaved off when no longer needed.
	Additional polypeptide sequence may promote correct folding of the polypeptide chain.
	Protection from premature degradation of the protein by cell proteases.

Answer 1