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is this true or false? Substituents in disubstituted cyclohexane conformations prefer only equatorial positions

is this true or false? Substituents in disubstituted cyclohexane conformations prefer only equatorial positions

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Answer #1

The stability of conformers of a given disubstituted cyclohexane is governed by the following rules:

a. The stability of a di-equatorial conformation is always greater than a di-axial conformation.

b. When one substituent is axial and the other is equatorial, then the most stable conformation will be the one in which the bulkier substituent is at the equatorial position.

Therefore, substituents in disubstituted cyclohexane conformations will prefer equatorial positions only.

Hence, the statement is True.

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