Question

Discuss the types of genetic variation that can lead to adverse drug reactions (Min 2 and...

Discuss the types of genetic variation that can lead to adverse drug reactions (Min 2 and a half pages).

Science   Biology   
0 0
Add a commentTranscribed image text
Next >

Homework Answers

Answer #1

The worldwide growing biobanks are a potential resource for studying the genetic variation leads to adverse drug reactions. One good example for gene-linked adverse drug reaction is the association of glucose-6-phosphate dehydrogenase (G6PD) polymorphisms with haemolytic anaemia. Severe haemolytic anaemia can occur in G6PD-deficient patients after the ingestion of fava beans and after the use of certain anti-malarial drugs or (sulphonamides).

One mechanism is an unusual drug accumulation due to drug-metabolizing enzyme-polymorphism. Variation in the target gene leads to the change in drug action is the second mechanism.

0 0
Know the answer?
Your Answer:

Post as a guest

Your Name:

What's your source?

Earn Coins

Coins can be redeemed for fabulous gifts.

Log In

Sign Up

Not the answer you're looking for?
Ask your own homework help question
Similar Questions
1. potential side effects and contraindication of the Afreeza drug 2. symptoms and adverse reactions of...
1. potential side effects and contraindication of the Afreeza drug 2. symptoms and adverse reactions of Afrezza drug ro report to providee ASAP
Describe the methods that can be used to analyze human gene expression. (Min 2 and a...
Describe the methods that can be used to analyze human gene expression. (Min 2 and a half pages)
1. Discuss how psychosocial factors can influence the development of childhood disorders. 2. Describe the drug...
1. Discuss how psychosocial factors can influence the development of childhood disorders. 2. Describe the drug and psychosocial therapies for ADHD. 3. Discuss the similarities and differences among conduct disorder, oppositional defiant disorder, and ADHD. 4. Discuss the symptoms and course of conduct disorder and oppositional defiant disorder. 5. Describe the genetic, neurological, hormonal, and temperamental contributors to conduct disorder and oppositional defiant disorder. 6. Discuss the parenting practices, social correlates, and cognitive factors that are associated with conduct disorder....
Discuss how fusion genes can originate from chromosomal breaks, and how these fusion genes can lead...
Discuss how fusion genes can originate from chromosomal breaks, and how these fusion genes can lead to cancer. (b) Within your answer, please discuss in detail the genotype, and how this leads to the phenotype of breast cancer (c) What genetic screening technique can be used to assess this disorder.
Research and Discuss variables and data types. 1. What are the various data types you can...
Research and Discuss variables and data types. 1. What are the various data types you can use in C#, Explain memory sizes of these data types? 2. Discuss string variables. What does a string variable provide? Provide details. 3. Provide examples how you would create a values like "Sarah", 2, 3.50, and store into memory. For example, DataType VariableName = "Sarah".
Medication errors by a nurse happen every day. In fact, adverse drug events account for almost...
Medication errors by a nurse happen every day. In fact, adverse drug events account for almost 700,000 ER visits and 100,000 hospitalizations every year. In many cases, these errors can lead to medical malpractice claims made against individual practitioners or even against entire health care teams. The majority of medication errors are preventable, and knowing how they happen can teach you what to be aware as future nurses. These five real-life medication error case studies that involved nurses. While these...
Chemical Reactions Types and Their Equations Making Heat with Chemical Reactions Have you ever wondered how...
Chemical Reactions Types and Their Equations Making Heat with Chemical Reactions Have you ever wondered how an instant heat pack works? A disposable heat pack works by a chemical reaction that combines iron in the package with oxygen from the air when the outer packaging is removed producing iron oxide. You have probably seen the product of this reaction in what is commonly called rust. The reaction releases heat, which allows the pack to reach a sufficient temperature that is...
1. Which statement about enzymes is true? A. One enzyme can catalyze many different types of...
1. Which statement about enzymes is true? A. One enzyme can catalyze many different types of reactions for a variety of substrates. B. The shape of an enzyme determines its specificity. C. Enzymes eliminate the activation energy barrier. 2. How would a cell with higher-than-average metabolism compare to a cell with normal metabolism during a specific period of time? A. It would produce larger amounts of waste. B. It would break down substances at the same rate. C. It would...
The half-reactions that occur in ordinary alkaline batteries can be written as Cathode:MnO2(s)+H2O(l)+e−→MnO(OH)(s)+OH−(aq)Anode:Zn(s)+2OH−(aq)→Zn(OH)2(s)+2e− In 1999, researchers...
The half-reactions that occur in ordinary alkaline batteries can be written as Cathode:MnO2(s)+H2O(l)+e−→MnO(OH)(s)+OH−(aq)Anode:Zn(s)+2OH−(aq)→Zn(OH)2(s)+2e− In 1999, researchers in Israel reported a new type of alkaline battery, called a "super-iron" battery. This battery uses the same anode reaction as an ordinary alkaline battery but involves the reduction of FeO2−4 ion (from K2FeO4) to solid Fe(OH)3 at the cathode. Part A Use the following standard reduction potential and any data from Appendixes C and D to calculate the standard cell potential expected for...
1. Read the article and discuss how operations can provide strategic advantage to this organisation. 2....
1. Read the article and discuss how operations can provide strategic advantage to this organisation. 2. Discuss the performance of the company in terms of the five performance objectives and the relationship among these performance objectives. 3. Discuss a suitable operations strategy approach for these kinds of organisations. Operations Strategy in Action Almost every company seems to be restructuring itself to face the downturn, be it through financial engineering, or by retrenching to core activities. So they sell off foreign...
ADVERTISEMENT
Need Online Homework Help?

Get Answers For Free
Most questions answered within 1 hours.

Ask a Question
ADVERTISEMENT