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Discuss the types of genetic variation that can lead to adverse drug reactions (Min 2 and...

Discuss the types of genetic variation that can lead to adverse drug reactions (Min 2 and a half pages).

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The worldwide growing biobanks are a potential resource for studying the genetic variation leads to adverse drug reactions. One good example for gene-linked adverse drug reaction is the association of glucose-6-phosphate dehydrogenase (G6PD) polymorphisms with haemolytic anaemia. Severe haemolytic anaemia can occur in G6PD-deficient patients after the ingestion of fava beans and after the use of certain anti-malarial drugs or (sulphonamides).

One mechanism is an unusual drug accumulation due to drug-metabolizing enzyme-polymorphism. Variation in the target gene leads to the change in drug action is the second mechanism.

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