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If a deletion occurs in a gene that encodes DNA helicase and no functional DNA helicase...

If a deletion occurs in a gene that encodes DNA helicase and no functional DNA helicase is produced, what will be the MOST DIRECT consequence of this mutation? The DNA will not be able to unwind to initiate replication The DNA would not be able to unwind at the replication forks DNA replication would be blocked on the lagging strand but would continue on the leading strand The DNA would not exist in a supercoiled state The DNA strands would contain pieces of RNA

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If a deletion occurs in a gene that encodes DNA helicase and no functional DNA helicase is produced, the most direct consequence will be the DNA will not be able to unwind to initiate replication. The main function of DNA Helicase is to hydrolize the Hydrogen bond between the base pair of two strand of DNA. There by separating the two strands of DNA so that they can act as a template for replication.

The detail mechanism of DNA Helicase is describe in the image, please go through it once:

For further queries please do comment. Thank you ?.

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