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Sam is a male and is the proband of the following pedigree. Sam is unaffected by...

Sam is a male and is the proband of the following pedigree. Sam is unaffected by the diseased trait; he has two sons and three daughters with his wife Kerry who is affected by the disease. Two of Sam and Kerry’s children have the diseased trait (one son and one daughter), the other children are unaffected. Sam’s parents did not show the diseased trait, but both Kerry’s parents were affected by the disease. Kerry’s brother (Sam’s brother in law) was unaffected by the disease.

With this information, draw the family pedigree of Sam and Kerry, assuming that the disease trait is completely dominant.

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Answer #1

Sam is unaffected & is shown in II-1. His parents are unaffected & is shown in I-1 & I-2. Kerry is II-2, her brother is II-3 & her parents are I-3 & I-4. Sam & Kerry's children are shown in generation III. Now, as already mentioned in the question that the disease is dominant, it can be either autosomal dominant or X-linked dominant.

If the trait is autosomal dominant:

Unaffected persons will be homozygous recessive. As II-3 is unaffected, I-3 & I-4 must be heterozygous. As II-2 has unaffected children, she must be heterozygous.

If the trait is X-linked dominant:

Unaffected persons will have wild type X chromosome. As II-3 is unaffected, I-4 must be heterozygous. As II-2 has unaffected children, she must be heterozygous.

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