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In the late 1990’s, an experiment was done in mice to “knock-out” the p21 gene; these...

In the late 1990’s, an experiment was done in mice to “knock-out” the p21 gene; these mice would now be unable to produce the p21 protein. What might be the consequences of eliminating the p21 protein

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  • p21 codes for a cyclin dependent kinase inhibitor (CKI). The protein binds to and inhibits cyclin-CDK 2,1,4/6 complexes
  • And thus functions as a regulator of cell cycle progression at G1 and S phase
  • Mice that lack this p21 gene will behave more like the embryonic stem cells than adult mammalian cells as it will not be able to inhibit cyclin-CDK 2,1,4/6 complexes
  • Due to the totipotency of the embryonic stem cells, the mice will now have the ability to regenerate damaged or missing tissue
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