Question

Tay-Sachs is an autosomal recessive disorder that results in progressive loss of brain tissue Jewish settlers and is engaged to Howard. Maria and Howard are concerned about having children since one of Maria’s uncles on her mother’s side had died from Tay Sachs. Howard’s family is of Scandinavian origin has no record of Tay Sach. You are asked to advise Maria and Howard as to the risk of them having a child with Tay Sachs. (FYI, the incidence of Tay Sachs in eastern European Jews is about 1/1000 and in other populations about 1/100,000). Construct a pedigree appropriate for this family and calculate the estimated risk for Maria and Howard to have a Tay-Sachs child. Show your calculations.

Answer 1