Question

Your professor has muted the N-terminal signal sequence that targets proteins to the ER in a manner that prevents it from being cleaved by proteases in the ER lumen. How will this effect the localization of the following proteins into the ER?

Answer 1

An ER signal sequence typically is located at the N-terminus of the protein and contains one or more positively charged amino acids followed by a continuous stretch of 6 – 12 hydrophobic residues (Table 17-4); except for these features, the signal sequences of different secretory proteins have little in common.

The general features of an N-terminal signal sequence that targets secretory proteins to the ER are that it has an ER signal sequencethat is located at the N-terminusof the protein, it has one or more positively charged amino acids, it has a specific hydrophobic.