Question

True or False

36.____  Formin is a regulator of actin bundling.

37._____ Proteoglycans are composed of GAG chains covalently linked to a core protein.

38.____ An actin filament is composed of two protofilaments that wind around each other as two parallel strands.

39._____ Driver mutations in tumor cells are thought to promote the cancer phenotype.

40. _____ GAGs are highly charged unbranched polysaccharide chains.

Answer 1

36. True - formin is multidomain proteins. It shows the nucleation, severing, and bundling activity in actin filament. It maintains the actin dynamics.

37. False - The proteoglycans unit consists of a core protein with more than one covalently attached GAG chain, which is covalently linked to serine residues of the protein backbone.

38. True - Actin filament consists of two parallel protofilaments that are twisted around each other in a right-handed helix.

39. True - Driver mutation is a type of mutation that gives a selective advantage to a clone in its microenvironment by increasing its survival or multiplication. Metastatic cell inherits driver mutation allowing persistence of tumorigenic ability.

40. True - GAG is an important component of extracellular matrix (ECM) as it is highly negatively charged polymer it bind with water and ions and create turgor pressure.