Question

Glipizide is a drug that increases insulin secretion by pancreatic β-cells and consequently lowers blood sugar. Which ONE of the following correctly describes the biochemical mechanism of action of this drug?

Choose the best answer

Glipizide inhibits calcium ion channels in the plasma membrane of pancreatic β-cells.

Glipizide inhibits potassium ion channels in the plasma membrane of pancreatic β-cells.

Glipizide activates glucokinase in pancreatic β-cells.

Glipizide binds to and inhibits the insulin receptor on pancreatic β-cells.

Glipizide inhibits the glucose transporter on prancreatic β-cells.

Answer 1

correct option is - TGLIPIZIDE INHIBITS POTASSIUM ION CHANNELS IN THE PLASMA MEMBRANE OF PANCREATIC B CELLS

Glipizide acts by partially blocking potassium channels among beta cells of pancreatic islets of Langerhans. By blocking potassium channels, the cell depolarizes, which results in the opening of voltage-gated calcium channels. The resulting calcium influx encourages insulin release from beta cells. thus no inhibition of calcium ion channels take place. if glipizide would inhibit any insulin receptor or glucose transporter then production of insulin will be inhibited thus it would work opposite rather than production