Question

What would happen to TRANSLATION if there was a nonsense mutation in the 5’ untranslated region of an mRNA? Explain your reasoning

Answer 1

There would be no effect on the translation process when the non sense mutation is found in 5' end of the untranslated region. The untranslated region provides the stability to mRNA only. This region is not translated into protein. The protein synthesis occurs between the start codon and stop codon. Hence if the mutation is found in between AUG and stop codon, then there is found effect of mutation only. That's why there is found normal translation of protein occurs.