Question

What is/are the phenotypes when Guanylyltransferase in 5' CAP is mutated at the Cellular Level? How does this genotype affect the phenotype of the cell?

Answer 1

Many eukaryotic Guanylyltransferase enzymes help in the  attachment of the 5' cap to messenger RNA molecules that are in the process of being synthesized in the cell nucleus during transcription.

Mutations in the Guanylyltransferase could lead to widespread reduction in protein expression by the cell.

Capping is essential for mRNA stability, enhancing mRNA processing, mRNA export and translation. Hence, absence of the capping mechanism would lead to decrease in the aformenioned mechanisms.