Question

There is a defect in the G2 cyclin such that it is never degraded. What effect, if any, would this have on the rate at which mutations accumulate as this cell-line continues to divide over many cell cycles? Explain your reasoning.

Answer 1

Cyclins are most important cell cycle regulators.Each step of the cell cycle is monitored by internal controls called checkpoints. There are three major checkpoints in the cell cycle: one near the end of G1, a second at the G2/M transition, and the third during metaphase. Positive regulator molecules allow the cell cycle to advance to the next stage. Negative regulator molecules monitor cellular conditions and can halt the cycle until specific requirements are met.If the there is a defect in the G2 cyclin such that it is never degraded, the chance of arresting the cell cycle at perticular phase is more.