Question

4.         What are the four mechanisms of regulating Cdks?

4.         What are the four mechanisms of regulating Cdks?

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Answer #1

Four regulatory mechanisms are :

  • Cyclin is the regulatory molecule which bind to the cyclin dependent protein kinase and allow the cdk to phosphorylate the target protein. Rise and fall in the concentration of the cyclin is responsible for the activation of the cdk molecule.
  • Phosphorylation of the threonine residues at 161 position of the cdk by cdk activating kinase( CAK) . This phosphorylation result in the conformation changes which increases the efficiency of the cdk to phosphorylate the protein effectively.
  • Cdk molecule are also regulated by the binding of cdk inhibitor. Binding of inhibitor to cdk prevent the cell cycle progression.
  • Cdk subunit get inhibited when tyrosine residues at 15 position get phosphorylated . Because of this cdk get inactivated . Cdc25 phosphatase remove the phosphate at 15 position and result in activation of CDK.
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