Question

4.         What are the four mechanisms of regulating Cdks?

4.         What are the four mechanisms of regulating Cdks?

Homework Answers

Answer #1

Four regulatory mechanisms are :

  • Cyclin is the regulatory molecule which bind to the cyclin dependent protein kinase and allow the cdk to phosphorylate the target protein. Rise and fall in the concentration of the cyclin is responsible for the activation of the cdk molecule.
  • Phosphorylation of the threonine residues at 161 position of the cdk by cdk activating kinase( CAK) . This phosphorylation result in the conformation changes which increases the efficiency of the cdk to phosphorylate the protein effectively.
  • Cdk molecule are also regulated by the binding of cdk inhibitor. Binding of inhibitor to cdk prevent the cell cycle progression.
  • Cdk subunit get inhibited when tyrosine residues at 15 position get phosphorylated . Because of this cdk get inactivated . Cdc25 phosphatase remove the phosphate at 15 position and result in activation of CDK.
Know the answer?
Your Answer:

Post as a guest

Your Name:

What's your source?

Earn Coins

Coins can be redeemed for fabulous gifts.

Not the answer you're looking for?
Ask your own homework help question
Similar Questions
Very briefly describe the two autoregulatory mechanisms for regulating glomerular filtration rate
Very briefly describe the two autoregulatory mechanisms for regulating glomerular filtration rate
Eukaryotes have a multitude of ways of regulating gene expression. Why are all these regulatory mechanisms...
Eukaryotes have a multitude of ways of regulating gene expression. Why are all these regulatory mechanisms important to the functioning of a eukaryotic organism? 10 marls
Explain the 4 ways that Cdks are regulated. Is it surprising the cell would have multiple...
Explain the 4 ways that Cdks are regulated. Is it surprising the cell would have multiple ways to control these cell cycle kinases?
What are the Pros and Cons of Regulating Wall Street.
What are the Pros and Cons of Regulating Wall Street.
What is the UK approach to regulating new financial products?
What is the UK approach to regulating new financial products?
What distinguishes a natural monopoly from other monopolies? What are the pros and cons of regulating...
What distinguishes a natural monopoly from other monopolies? What are the pros and cons of regulating natural monopolies? Does your answer differ depending on the specific product or industry being regulated?
What are the two approaches to regulating a monopoly? name them, show the diagram, and discuss...
What are the two approaches to regulating a monopoly? name them, show the diagram, and discuss the dilemma (the natural monopoly case with a flat MC).
What are the mechanisms to create cell memory?
What are the mechanisms to create cell memory?
what mechanisms/machineries may be inhibited if the CTD tail has mutations? What problems could be encountered...
what mechanisms/machineries may be inhibited if the CTD tail has mutations? What problems could be encountered in RNA processing in these cell lines if there are mutations? list four things that can go wrong with RNA processing if there is a problem with the CTD tail.
Cell biology 1. Briefly describe what occurs in the four phases of the cell cycle (G1,...
Cell biology 1. Briefly describe what occurs in the four phases of the cell cycle (G1, S, G2, M). 2. How does cyclin regulate cyclin-dependent kinases (Cdks)? Why do Cdks require cyclin? 3. Mitogens are involved in cell signaling pathways which promote cell division by the production of cyclin. Using the figure 18-14 from your book (which is on the right), answer whether the expression of genes required for cell proliferation will be increased or decreased under the following scenarios....