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Discuss 3 biochemical strategies used in the fight against plasmodium infections

Discuss 3 biochemical strategies used in the fight against plasmodium infections

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There are following three biochemical strategies effective against Plasmodium infection:

First, inhibition of the folate pathway in plasmodium by using a drug against GTP cyclohydrolase I, a rate-limiting enzyme.

Second, the use of antifolate pyrimethamine and sulphadoxine against dihydrofolate reductase (DHFR) and dihydropteroate synthase (DHPS), respectively is also an effective treatment.

Third, the use of 7-chloro-4-amino-quinoline is an effective treatment against malaria. It inhibits the Hb digestion pathway.

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