Question

In DNA replication, what is the difference between replicating the leading versus the lagging DNA strands?

In DNA replication, what is the difference between replicating the leading versus the lagging DNA strands?

Homework Answers

Answer #1
Leading strand replication lagging strand replication
Synthesized continuously synthesized discontinuously in small fragments known as Okazaki fragments.
the opening of double helix occurs in 3' to 5' direction the opening of double helix occurs in 5' to 3' direction
grows in 5' to 3' direction grows in 3' to 5' direction
elongation starts at the beginning of replication elongation occurs a bit later after initiation of replication
grows towards the replication fork grows away from replication forks
does not require DNA ligase requires DNA ligase to join the Okazaki fragments
replication occurs with high speed replication is slow compare to the lagging strand
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