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Given your insights into nucleosomal remodeling, speculate on the effects of a drug that competitively blocks...

Given your insights into nucleosomal remodeling, speculate on the effects of a drug that competitively blocks ATP binding site in the RSC complex in yeast.

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Chromatin modifications occurs by Nucleosome remodeling. The chromatin modifications that can influence genome expression in nucleosome remodeling. Nucleosome remodeling does not involve covalent modifications of histone proteins .

Remodeling involves a change in the structure of the nucleosome and Change in its position. It is induced by an energy dependent process that weakness the contact between the histones and the DNA with which it's associated.

Change in position involves both cis and trans displacement that involves movement of nucleosome. ATP dependent chromatin remodeling complexes responsible for nucleosome remodeling. Two best studies classes of these complexes are the swi/snf family and the ISWI based family

RSC complex in yeast important for function.when drugs block this pathway then ATP dependent process does not occur because nucleosome remodeling dependent on

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