Question

Assert if the following are either cooperativity or allostery:      

a. An insulin binding to a GPCR triggers many conformational changes in the GPCR.

b. Annexins are remodeling proteins with membrane binding affinity that can be increased in the presence of calcium ions.

c. When valium (a narcotic) binds to a GABA receptor, the receptor's affinity for binding to GABA increases.

d. Once phosphorylated, phosphorylase kinase adopts a new structure that is functional.

Answer 1

Insulin does'nt bind to GPCR, Annexins act on the membrane of the cell and can help in the distribution of calcium ions in the cells. Valium, which is also known as diazepam, a drug widely used to treat insomnea, anxiety and depression. This benzodiazepene drug bind to GABA (a neurotransmitter) receptor and subsequently through this process it increases the affinity of GABA increases and this phenomena act cooperativity. Therefore, the correct answer would be c. "When valium (a narcotic) binds to a GABA receptor, the receptor's affinity for binding to GABA increases"