Which protein—(a) clathrin or (b) a transcription factor—would be most likely to have a selectively exposed nuclear localization sequence? Why?
clathrin is a protein which has a triskelion structure, it binds to the membrane and causes the invagination of the membrane which facilitates the formation of vesicles, clathrin protein does not have nuclear localization signal it does not have to translocate to the nucleus, it functions in the cytosol.
transcription factors are translated in the cytosol and it has to translocate to the nucleus to function, transcription factors bind to the specific sequences on the DNA and regulate the expression of the genes.
for proteins to translocate to the nucleus from the cytosol, it has to have a nuclear localization signal, so transcription factors have nuclear localization signal.
so the answer is b)a transcription factor
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