Degenerative nerve diseases are mainly caused by losd neurons
function in body leads to loss of body activities, such as balance,
movement, talking, breathing, and heart function. Most of these
diseases are genetic in nature.
Main diseases are
- Alzheimer's Disease: protein misfolding of beta amyloid
protein
- Amyotrophic Lateral Sclerosis (ALS): missense mutations in the
gene encoding the antioxidant enzyme Cu/Zn superoxide dismutase 1
in astrocytes leads to loss of motor function.
- Parkinsons disease: accumulation of alpha synuclein in
neurones.
- Prions: proteinaceous causitive agents and these are
transmissible spongiform encephalopathies (TSE's) are a group of
progressive neurodegenerative conditions and caused by prion
protein.
- Huntington disease: loss of transport of proteins to lysosomal
system and loss of function of dynin and microtubules