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Consider how bone marrow transplantation can rescue a defective or ablated immune system. What properties are...

Consider how bone marrow transplantation can rescue a defective or ablated immune system. What properties are required for the transplanted cells to reconstitute a normal immune system? Is it equivalent to use bone marrow or hematopoetic stem cells isolated from the blood?

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Answer #1

Accumulated evidences demonstrate that active function and trafficking of immune cells, including regulatory T cells, conventional T cells, B cells, dendritic cells, natural killer T (NKT) cells, neutrophils, myeloid-derived suppressor cells and mesenchymal stem cells, are observed in the bone marrow. Thus a bone marrow transplant can rescue a defective or ablated immune system.

one has to consider the HLA gene matching before the transplant so as to reconstitute the normal immune system.

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