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which conditions can arise if too much VEGF is produced?

which conditions can arise if too much VEGF is produced?

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Answer #1

VEGF (Vascular endothelial growth factor) inhibits Dnase. The following are the series of events that occur upon the activation of VEGF receptors.

VEGF binds to the VEGF receptors ----------> Dimerization and phosphorylation of VEGFR intracellular domain ---------> Phosphorylation of Akt (activated) ------------> Inhibition of caspase 3 ----------> Breakdowns DNAse inhibitor ----------> DNAse inhibitor binds with DNAse ----------> Inactivation of DNAse.

Excessive production of VEGF results in cardiovascular diseases, cancer, diseases of the brain vasculature, renal diseases, ocular diseases, and many others.

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