Question

Describe feedback inhibition inn terms of enzymes, substrates and products formed. Why does it occur?

Answer 1

The enzyme activity at the branch points of metabolic pathways is generally regulated by the end-point inhibition or feedback inhibition. Means, the increased product formation inhibits the further formation of the same product. This negative feedback loop is known as “end product inhibition.”

The end product in the equation binds to the enzyme at the branch point and thus, inhibits the formation of the production. This prevents the accumulation of the end product. In allosteric inhibition, the final product inhibits the earlier enzymatic step in the pathway. The allosteric inhibitor binds to the allosteric site (other than the active site). So that the altered shape of the enzyme inhibits the substrate to bind to the active site.