Question

Using a cancer with a hereditary component as an example, explain how aninherited gene abnormality increases the risk for cancer. Use an example other than the p53 gene in answering the question.

Answer 1

Hereditary cancers:-

Cancers that occur because of an inherited mutation are called hereditary cancers.

AN INHERITED GENE ABNORMALLY INCREASE THE RISK FOR CANCER:-

Hereditary breast and ovarian cancer syndrome is example for hereditary cancers.

many women develop breast cancer or ovarian cancer, Often found in women who are younger than the usual age and some women might have more than one cancer (such as breast cancer in both breasts, or both breast and ovarian cancer). This is known as Hereditary Breast and Ovarian Cancer syndrome .

Most often, HBOC is caused by an inherited mutation in either the BRCA1 or BRCA2 gene.

The risk of breast and ovarian cancer is very high in women with mutations in either BRCA1 or BRCA2, but it tends to be higher with BRCA1 mutations. Along with breast and ovarian cancer, this syndrome can also lead to fallopian tube cancer, primary peritoneal cancer.