Question

Cells can regulate precisely where signaling occurs within the cell (e.g., in the yeast mating pathway) by association of the signal pathway proteins with a ________.

A mutation in RTK receptor that allows the receptor to bind the ligand and pair with a wild-type receptor but blocks signal transduction is classified as a ________ ________ mutation, whereas a mutation that activates RTK pairing signal transduction even in the absence of ligand is classified as a ______________ _______ mutation.

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Answer 1

Cells can regulate precisely where signaling occurs within the cell (e.g., in the yeast mating pathway) by association of the signal pathway proteins with a RECEPTOR

A mutation in RTK receptor that allows the receptor to bind the ligand and pair with a wild-type receptor but blocks signal transduction is classified as a LOSS-OF-FUNCTION mutation mutation, whereas a mutation that activates RTK pairing signal transduction even in the absence of ligand is classified as a CONSTITUTIVE MUTATION mutation.