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List and explain all possible scenarios where production of an altered tubulin protein harms a human

List and explain all possible scenarios where production of an altered tubulin protein harms a human

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Tubulin is a component of the cytoskeleton. It is also essential for movement and cell division. Tubulin is vital for the maintenance and dynamics of eukaryotic cells.

Mutations in tubulin genes predominantly affect the nervous system.

a. Tubulinopathies = Malformation of the brain due to mutations in tubulin gene.

Ex: Microlissencephaly, lissencephaly and cortical dysplasia.

b. Neurodegenration

Ex: Frontotemporal dementia

c. Ciliopathies

Ex: Immotile cilia syndrome.

d. Male infertility

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