Question

​Is the replication strategy of Sindbis virus similar/different from poliovirus? Explain!

Answer 1

Both Sindbis (Togaviridae family) and Polio (Picornaviridae) are RNA viruses but have different mechanism of replication.

In Polio virus Genome is sense strand. It may act as template for negetive strand synthesis. Negetive strand give many positive strand out of which it may translated or may enveloped.

But in Sindbis virus Genome is having 5'Cap and Tail at 3' end. 5' end codes for protein helpful in synthesis of RNA in replication and at 3' end codes for two envelope proteins. RNA is translated partially and protein formed help in synthesis of sub genomic RNA. Sub genomic RNA are either enveloped on host surface or translated.