Question

What do these chemicals do: Histamine, Prostaglandins, IL-1, TNF-α, IL-6, IL-12, kinins

Answer 1

1. Histamine - it increases the permeability of capillaries going to white blood cells and some proteins. In turn it allows the engagement of pathogens in the infected tissue.

2. Prostaglandins - it stimulates inflammatory response in most of the organs. It stimulates nerves that thereby sense the message of pain into the brain.

3. IL-1 - it has a key role in the activation of innate immunity.

4. TNF- alpha - it is involved in the regulation of immune cells. It induces fever, apoptosis.

5. IL-6 - it plays a role in inflammation as well as in the maturation of B-cells.

6. IL-12 - it promotes the development of Th1 responses and also induces the production of IFNgamma by T and NK cells. It has a role in immune homeostasis.

7. Kinins - it causes inflammation and affects the blood pressure. It is involved in increasing the blood flow throughout the body.