Buchner, D.A., Charrier, A., Srinivasan, E., Wang, L., Paulsen, M.T., Ljungman, M., Bridges, D., and Saltiel, A.R. 2015. Zinc Finger Protein 407 (ZFP407) regulates insulin-stimulated glucose uptake and glucose transporter 4 (Glut4) mRNA. Journal of Biological Chemistry, 290: 6376-6386.
Above is link. It is article.
What hypothesis do the authors propose?
What is the role of GLUT4?
What is the relationship between GLUT4 function and type 2 diabetes?
What is ZFP407? How was it identified?
How did the authors demonstrate the role of ZFP407?
What is the significance of this study?
Role of GLUT 4: GLUT4 helps in glucose uptake in peripheral tissues under influence of Insulin hormone.
Relationship between GLUT 4 and Type 2 diabetes: In type 2 diabetes GLUT 4 function gets disrupted that leads to hyperglycemia i.e more glucose in body fluids.
What is ZFP407? How was it identified?ZFP407 is a protein. It was identified through a targeted siRNA screen.
Role of ZFP407: it regulates many peroxisome proliferator activated receptor target genes and acts as a modulator of PPAR signaling pathway.
Significance of this study: It helps to understand type 2 diabetes and will help to find a cure for the disease through understanding of signaling pathway.
Get Answers For Free
Most questions answered within 1 hours.