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ATP can act as an allosteric regulator molecule?

ATP can act as an allosteric regulator molecule?
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Even when ATP is a substrate of the enzyme, it acts as a negative allosteric modulator for phosphofructokinase (PFK). Negative allosteric modulation is observed between ATP and phosphofructokinase within the negative feedback loop that controls glycolysis.

When ATP levels are high, it binds to an allosteoric site on PFK. This results in a change in the enzyme's shape and this decreses the affinity for substrate at the active site and the enzyme gets disabled. This reduces the process of glycolysis and maintain balanced levels of cellular ATP.

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