Question

Compare and Contrast the structure and function of AMPA-subtype and NMDA-subtype glutamate receptors. In your answer be sure to discuss similarities and differences in receptor regulation, ion conductance, and influence on neurotransmission

Answer 1

Hi,
The NMDA and AMPA are two of the three subtypes of glutamate receptors. These are named as per the ligand which activates them. Both these reeptors are non selective cattion channels which allow passage of Na+ and K+ ions. Both these receptors produce post synaptic excitations. One of the unique feature of NMDA receptors is that they allow movememnt of Ca2+ in addition to Na+ and K+. The opening of NMDA receptos require the presence of co-agonist , glycine and the hyperpolarized channls are bloced by Mg+2. The AMPA are the first post synaptic recepors to get activated. These two receptos also differ in their speed. The AMPA recpetor conductance rise and decrease fast as compared to NMDA.