Question

Which of the following is not an important ER-resident enzyme that modifies proteins in the secretory...

Which of the following is not an important ER-resident enzyme that modifies proteins in the secretory pathway?

A. BiP

B. Oligosaccharyl transferase

C. Sec61

D. Protein disulfide isomerase

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Homework Answers

Answer #1

Sec61 is a translocon found on the ER membrane through which the proteins are translocated into the ER and does not involve in the protein modification in the secretory pathway.

BiP is a chaperone found inside the lumen of the ER and binds to the protein once it has entered and maintained the protein in a stable conformation.

Oligosaccharyl transferase is the enzyme in the ER lumen which involves in the addition of sugars to the protein(Glycosylation).

Protein disulfide isomerase involves in the formation and breakdown of disulfide bonds within the protein as they fold.

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