In complex disorders, common genetic risk variants can be identified by:
a) linkage analysis and sequencing of positional candidate genes
b) genome wide association studies
c) whole exome sequencing
d) a and b
e) a and c
Answer: Option D is correct.
Complex disorders are difficult to study as they are affected by both genetic and environmental factors. To study such disorders, we can perform QTL analysis and identify the potential candidate genes. These candidate genes can further be verified by GWAS (genome-wide association studies). The association studies will reveal whether a given candidate gene is the causative agent of the disorder in a given environmental condition.
In most cases, GWAS studies involve whole genome sequencing if the objective is to look for the SNPs at the DNA level.
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