Question

Describe in detail how an Anthrax toxin can use a eukaryotic cell to reach its target

Answer 1

Anthrax toxin reaches its target in an eukaryotic cell through the following steps:
1) Toxin activation-(proteolytic cleavage to gain full biological activity)
2) Receptor binding (After activation bind to its receptor)
3) receptor-mediated endocytosis (actively transporting Anthrax toxin into the cell by engulfing it with its membrane)
4) Vesicle transport (transport across the vesicle membrane)
5) Translocation of active toxin from vesicular compartments in to cytosol (target).