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Dentinogenesis imperfecta is a tooth disorder. The trait is inherited as an autosomal dominant allele in...

Dentinogenesis imperfecta is a tooth disorder. The trait is inherited as an autosomal dominant allele in humans. Assume that a male with dentinogenesis imperfecta, whose mother had normal teeth, married a woman with normal teeth. They had four children.

What is the probability that their first child will be a male with dentinogenesis imperfecta?

What is the probability that three of their four children will have the disease?
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Answer #1

Autosomal diseases spread in normal inheritance pattern. Here the allele is dominant and so the pattern will be normal inheritance. When the male has dentinogenesis imperfecta but the mother has a normal teeth, probably the father of the male had inherited the dominant allele and has been passed on to him. He marries a woman with normal teeth and bears 4 children.

The probability therefore the first child will be a male is 0.5 and the male will have dentinogenesis imperfecta is 0.5. Together the probability is 0.25.

Similarly the probability that 3 of the 4 children will have this disease will be 0.5 for every child.

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