Question

(Cell Biology) Identify examples of misfolding that lead to accumulation of the protein resulting in disease. (One paragraph)

Answer 1

S. No.	Disease	Protein/peptide
1	Alzheimer's disease	Aβ peptides (1–40, 1–41, 1–42, 1–43); Tau
2	Parkinson's disease	α-synuclein (wild type or mutant)
3	Atrial amyloidosis	Atrial natriuretic factor
4	Familial amyloid polyneuropathy III	Apolipoprotein A-1 (fragments)
5	Huntington disease	Huntingtin (polyQ expansion)
6	Hemodialysis-related amyloidosis	β2-microglobulin
7	Amyotrophic lateral sclerosis	Superoxide dismutase (wild type or mutant)
8	Lysozyme systemic amyloidosis	Lysozyme (full-length, mutant)
9	Spino cerebellar ataxia 17	TATA box-binding protein (polyQ expansion)
10	Kennedy disease	Androgen receptor (polyQ expansion)
11	Spongiform encephalopathies	Prion protein
12	Fronto-temporal dementias	Tau (wild type or mutant)