Question

Human ABO blood type is determined by three alleles (IA, IB, and i) whose gene products...

Human ABO blood type is determined by three alleles (IA, IB, and i) whose gene products modify the H antigen produced by protein activity of an independently assorting H gene. A rare abnormality known as the “Bombay phenotype” is the result of epistatic interaction between the gene for the ABO blood group and the H gene. Individuals with the Bombay phenotype appear to have blood type O based on the inability of both anti-A antibody and anti-B antibody to detect an antigen. The apparent blood type O in Bombay phenotype is due to the absence of H antigen as a result of homozygous recessive mutations of the H gene. Individuals with the Bombay phenotype have the hh genotype. Use the information above to make predictions about the outcome of the cross shown below: IAI B Hh×IAIB Hh

Part A

For this cross, what fraction will have type O blood?

Express your answer as a fraction. Example: 1/8

For this cross,  will have type O blood.

Part B

For this cross, what fraction will have type A blood?

Express your answer as a fraction. Example: 1/8

For this cross,  will have type A blood.

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Part C

For this cross, what fraction will have type AB blood?

Express your answer as a fraction. Example: 1/8

For this cross,  will have type AB blood.

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Part D

For this cross, what fraction will have type B blood?

Express your answer as a fraction. Example: 1/8

For this cross,  will have type B blood.

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