Question

In your own words please and be as specific.

What is the significance of IL-17 for Giardia immunity? What cells are involved in secreting IL-17, what Giardia antigens are invovled and is the response innate, humoral or cell-mediated? Provide an explanation using the research article to support your response.

Answer 1

Giardia is involved as pathogen of diaorrhea and IL-17 are important cytokines in the providinp immunity against the pathogen These cytokines are relaesered from the TL-17 T-cells. These activates the host defence in the intestine by incrsaincrethe defenece molecules like beta defensin in the cell. First response is the inflammation caused by the IL-17 cytokines indicating the pathogen attack and stimulating the intestine for the production of defensins. Hence it is a cell mediated response.

Articles -

IL-17A promotes protective IgA responses and expression of other potential effectors against the lumen-dwelling enteric parasite Giardia.

Link-https://www.ncbi.nlm.nih.gov/m/pubmed/26071205/#fft