Question

For the mutation, predict the effect pf the mutation on the eventual protein product and explain....

For the mutation, predict the effect pf the mutation on the eventual protein product and explain.

a) a mutation that deletes the entire leader region

b)a mutation that inserts exactly four base pairs in the middle of intron 2

c) a mutation that deletes exactly three base pairs at the very beginning on exon 3

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Answer #1

a. The leader sequence is important for the translation of the coding sequence. The leader sequence is also known as 5'-UTR. It is often involved in the regulation of translation. If the leader sequence is deleted, most likely the protein product won't be formed.

b. Introns are removed during splicing. They are not part of the mature mRNA. So, it does not affect the protein if there are in-del mutations in the intron (Assuming that they are not affecting splicing).

c. The genetic code is triplet. So, if we insert extra 3 nucleotides at the beginning of exon 3, only one extra amino acid will be inserted in the protein with no frame-shift in the downstream sequence.

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