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A protein binds a drug (ligand A) with a dissociation constant (Kd) of 1 nM (nanomolar,...

A protein binds a drug (ligand A) with a dissociation constant (Kd) of 1 nM (nanomolar, 10-9 M). The same protein binds a modified drug (ligand B) with a Kd of 1 pM (picomolar, 10-12 M).

Which drug binds more tightly?

What is the ΔG value for dissociation of each of these two interactions? Show your work and provide your answer in units of kcal/mol. Assume the measurement is at 25 °C.

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