Question

Match each antibiotic with its correct target. Each answer may be used only once!

Antibiotics: cefotaxime, vancomycin, bacitracin

Targets:

A. transglycosylase

B. transpeptidase

C. undecaprenyl diphosphatase

Answer 1

Targets:

A. transglycosylase : vancomycin

B. transpeptidase : cefotaxime

C. undecaprenyl diphosphatase : bacitracin

Bacitracin : Involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, therefore, reducesthe pool of lipid carriers .

Cefotaxime inhibits mucopeptide synthesis by binding to and inactivating penicillin binding proteins so interfere with the last transpeptidation step .

Vancomycin target enzymes that facilitate cell wall formation. These are family of glycopeptides. They are large molecules that bind to the peptide chain of peptidoglycan
subunits by blocking transglycosylation....