Question

During DNA replication, why is replication of the lagging DNA strand a problem compared to the...

During DNA replication, why is replication of the lagging DNA strand a problem compared to the leading DNA strand, and how is this problem overcome?

Homework Answers

Answer #1

Unlike the bacterial chromosomes, the chromosomes of the eukaryotes are linear that is rod-shaped, which means that they have ends. These ends can pose a problem for DNA replication. The DNA which is at the very end of the chromosome will not be fully copied in each round of replication, which will result in a slow, gradual shortening of the chromosome.

Telomerase solves the "end replication problem."

Leading and lagging strands which are produced during the process of replication in eukaryotes. Although DNA polymerase can very easily replace internal RNA primers of the lagging strand with DNA, the replacement of the 5’ RNA primer requires the extension of the 3’ single-stranded parental DNA by telomerase.

Know the answer?
Your Answer:

Post as a guest

Your Name:

What's your source?

Earn Coins

Coins can be redeemed for fabulous gifts.

Not the answer you're looking for?
Ask your own homework help question
Similar Questions
List 3 enzymes involved in DNA replication that get used MORE in building of the lagging...
List 3 enzymes involved in DNA replication that get used MORE in building of the lagging strand (as compared to that of the leading strand). Describe why. Describe how DNA replication is carried out on the lagging strand.
Describe lagging strand synthesis during DNA replication.
Describe lagging strand synthesis during DNA replication.
DNA replication is _________ on the leading strand and __________ on the lagging strand. 1. discontinuous,...
DNA replication is _________ on the leading strand and __________ on the lagging strand. 1. discontinuous, continuous 2. recombinant, nonrecombinant 3. conservative, semiconservative 4. continuous, discontinuous 5. dispersive, discontinuous
Describe the difference between the replication of the leading and the lagging strand of DNA in...
Describe the difference between the replication of the leading and the lagging strand of DNA in E. coli.
QUESTION 1 * Compared to the leading strand, the lagging strand requires ________ primers.?? A. more...
QUESTION 1 * Compared to the leading strand, the lagging strand requires ________ primers.?? A. more B. the same number of C. less QUESTION 2 * Which enzyme synthesizes the majority of the DNA polymer for both the leading and lagging strands??? A. DNA polymerase I B. primase C. DNA polymerase III D. helicase QUESTION 3 * For each origin of replication, how many DNA polymerase III enzymes are needed??? A. 1 B. 8 C. 4 D. 2 QUESTION 4...
During DNA replication, DNA polymerase is only used to replicate the leading strand (Polymerase is not...
During DNA replication, DNA polymerase is only used to replicate the leading strand (Polymerase is not used on the lagging strand). True False The phrase "DNA replicating away from helicase" describes the lagging strand. True False The phosphate-sugar backbone connects nucleotides within a strand using ____ bonds between the phosphate of one nucleotide and carbon number ___ of the previous nucleotide. hydrogen..... 5' covalent..... 3' covalent..... 5' hydrogen..... 3' Which bonds are broken during DNA replication? hydrogen bonds phosphodiester bonds...
Explain how the synthesis of the lagging strand occurs in DNA replication.
Explain how the synthesis of the lagging strand occurs in DNA replication.
During DNA replication, the lagging strand is produced by linking together many Okazaki fragments. Please describe...
During DNA replication, the lagging strand is produced by linking together many Okazaki fragments. Please describe the enzymes and processes involved in producing 2 Okazaki fragments and linking them together into a single small strand of DNA.
Describe the synthesis of leading strand during DNA replication. Assume the replication bubbled is open and...
Describe the synthesis of leading strand during DNA replication. Assume the replication bubbled is open and helicase has already opened the strand.
Identify each of the enzymes involved in DNA replication and whether they are used during synthesis...
Identify each of the enzymes involved in DNA replication and whether they are used during synthesis of the leading strand, lagging strand, or both. And briefly explain their function during DNA replication. Enzymes: DNA Polymerases I and III, Topoisomerase, Helicase, Ligase, SSBPs
ADVERTISEMENT
Need Online Homework Help?

Get Answers For Free
Most questions answered within 1 hours.

Ask a Question
ADVERTISEMENT