Question

Using pedigree diagrams which you generate yourself, calculate the inbreeding coefficient (F) for the offspring of the following matings. You should interpret F as Pr(focal individual is homozygous for any allele of a MRCA)

(a) parent–offspring matings;

(b) first-cousin matings;

(c) aunt– nephew matings;

(d) self-fertilization of a hermaphrodite.

11) The incidence of PKU varies between populations. Using the incidence data below, estimate the frequency of null PAH mutants based on the frequency of the PKU disorder for the following populations

          a) Turkey: 1/2600

          b) Europe: 1/10,000

c) Japan: 1/120,000

12) Referring back to the previous two questions, imagine that the MRCA was a known carrier for the recessive disorder PKU. What is the fold increase in risk of the offspring suffering from PKU for an offspring produced by two cousins vs. an offspring produced by one of these cousins and an unrelated individual in

          (a) Turkey

          (b) Europe

          (c) Japan

Answer 1